They suppress the T-Helper 1 (TH1) response, thereby reducing the release of interferon gamma and tumor necrosis factor alpha associated with MS episodes, in addition to increasing the TH2 response related to the circulation of interleukins 4 and 10, involved in maternal immune tolerance toward the presence of the fetus, thereby reducing the intensity and number of episodes of MS during pregnancy (Fragoso et al., 2018). This evidence concerns the gene TNF and myeloid sarcoma.