TNF‐α, IL‐1β, and IL‐6 are critical cytokines during infection and elevated levels of these cytokines are associated with sepsis.22, 23 On other hand, inhibition of these cytokines by antagonists, neutralization antibodies, and specific inhibitors reduces the inflammatory response and ameliorates symptoms in both experimental animals and clinical patients,24, 25, 26, 27 indicating targeting inflammatory cytokines could treat sepsis. The gene discussed is IL1B; the disease is Sepsis.