Methods: We designed this study to investigate the effect of lncRNA linc00152 on rheumatoid arthritis inflammation and explore its molecular mechanism.Result: We found that linc00152 was not only up‐regulated in rheumatoid arthritis fibroblast‐like synoviocytes (RAFLS), but also stimulated by TNF‐α/IL‐1β in adose‐ and time‐dependent manner in RAFLS and this expression depends on the NF‐κB signaling pathway. Here, TNF is linked to rheumatoid arthritis.