HLA-C and infection: These three candidate pairs were further evaluated with three complementary methods: (1) a further cross-sectional analysis examining the presence of an interaction term between infection time and HLA type, (2) a longitudinal survival analysis examining time to the DRM detection among treatment-naïve patients initially without the queried DRM detectable, and (3) NetMHCPan MHC binding prediction analysis to examine mechanistic plausibility.