In strong support of this finding, imbalanced transcription of the two endogenous BEST1 alleles was detected in donor-derived iPSC-RPE and native RPE cells (Table 1), consistent with the previous observation that BEST1 is one of the inherited retinal disease genes with AEI in the human retinal transcriptome (Llavona et al., 2017). This evidence concerns the gene BEST1 and Abnormal retinal morphology.