Furthermore, analyses considering sociodemographic and clinical data demonstrated that the percentage of variation in BDNF levels was significantly lower for those who had a first-degree relative with alcohol dependence (14.8 [-5.3;35.6] vs. 35.3 [15.4;74.8]; p = 0.005,Table 1andFigure 1B). Here, BDNF is linked to alcohol dependence.