Beyond use of drugs, other factors may also be related to the BDNF variation during alcohol abstinence and could be influencing the results detected so far, including age, sex, and age at first drug use, 5 presence of psychiatric disorders, 20,21 neurodegenerative diseases, chronic inflammatory state, 22 tobacco consumption, 23 family history of alcohol, 24,25 and genetic predisposition. The gene discussed is BDNF; the disease is psychiatric disorder.