CD4 and neoplasm: This analysis revealed that OVV-MnSOD administration was associated with a significant increase in the frequency of CD8+ T cells, CD4+ T cells, Treg, NK cells, and dendritic cells (DCs) within EL4 and A20 tumors relative to those treated with PBS, and to increase the frequency of CD8+ T cells, CD4+ T cells, and DCs in both of these tumor types relative to OVV treatment (Figure 3C,D).