NCT dysfunction has been reported in AD (Eftekharzadeh et al., 2018), HD (Gasset-Rosa et al., 2017; Grima et al., 2017), and ALS/FTD (Chou et al., 2018; Zhang et al., 2015), and mutation in NUP62 causes autosomal recessive infantile bilateral striatal necrosis (Basel-Vanagaite et al., 2006), suggesting a common disrupted pathway. The gene discussed is NUP62; the disease is Alzheimer disease.