The NPC pathway has not previously been linked to trauma-mediated neurodegeneration but has been reported to be disrupted in ALS/FTD, AD, HD, and other neurodegenerative diseases (Chou et al., 2018; Eftekharzadeh et al., 2018; Grima et al., 2017; Zhang et al., 2015). Here, NPC1 is linked to amyotrophic lateral sclerosis.