KPT-350 and KPT-276 show neuroprotection in C9orf72 mediated ALS neurons and Drosophila models Tamir et al., 2017; Zhang et al., 2015; KPT-350 reduce cell death in rodent primary cortical neurons expressing HD protein Grima et al., 2017; and KPT-350 protect cortical circuit function and survival of inhibitory interneurons as well as reduce TBI-induced behavioral and histological deficits in a CCI model of TBI (Cantu et al., 2016; Tajiri et al., 2016). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.