A recurrent chromosomal translocation found in the majority of Ewing sarcoma fuses the Ewing sarcoma breakpoint region 1 or RNA‐binding protein EWS (EWSR1) and Friend leukemia integration 1 transcription factor (FLI1) genes generating an EWS–FLI1 fusion protein. Here, EWSR1 is linked to Ewing sarcoma.