These data cumulatively suggest that OTUD7A inactivation not only impedes Ewing cell growth largely through reduced EWS–FLI1 protein stability, but also inhibits Ewing sarcoma motility through an EWS–FLI1‐independent manner, possibly by regulating the levels of cell–cell‐adhesion‐related proteins (Figure S13L, Supporting Information). The gene discussed is FLI1; the disease is Ewing sarcoma.