FLI1 and Ewing sarcoma: By contrast, depletion of endogenous OTUD7A in non‐Ewing sarcoma cells, such as MDA‐MB‐231 cells, by either tet‐inducible shOTUD7A (Figure 3G) or stable OTUD7A depletion (Figure S9F,G, Supporting Information) did not significantly affect cell growth in vitro, although it reduced endogenous FLI1 protein abundance (Figure 3G and Figure S9H (Supporting Information)).