MYH6 and myocardial infarction: Conditional overexpressing of the cluster in early and late embryonic heart, using Nkx2.5-Cre and Myh6-Cre respectively, led to increased cardiomyocyte proliferation (Chen et al. 2013), and induced overexpression of the cluster in adult cardiomyocyte using Myh6-CreERT2 also enhanced proliferation of the cardiomyocyte and protected the heart from MI injury with smaller scars (Chen et al. 2013).