miR-210’s role in cardiomyocyte proliferation was revealed in a subsequent study, in which miR-210 showed pro-proliferation activity on adult rat cardiomyocytes (Arif et al. 2017), and its transgenic overexpression led to a significant increase in CM proliferation after myocardial infarction (Arif et al. 2017) Adenomatous polyposis coli (APC), a core component of Wnt signaling pathway that is a suppressor of proliferation, was identified as the direct functional target of miR-210 (Arif et al. 2017). The gene discussed is APC; the disease is myocardial infarction.