TGM2 and cranioectodermal dysplasia: P57-68 is the most potent DQ2-restricted T-cell stimulatory gliadin sequence where TG2-mediated deamidation plays a crucial role for HLA binding (Arentz-Hansen et al. 2000), while 31–43 is a unique α-gliadin fragment that can activate the innate immunity in CeD patients by causing cellular stress (Barone et al. 2014).