Univariate logistic regression analysis showed female age (OR 1.117; 95% CI 1.107–1.128; P < 0.001), male age (OR 1.052; 95% CI 1.047–1.057; P < 0.001), body mass index (OR 1.021; 95% CI 1.011–1.032; P < 0.001), basic FSH (OR 1.044; 95% CI 1.028–1.061; P < 0.001), basic P (OR 0.835; 95% CI 0.751–0.929; P = 0.001), anti-Mulller hormones (OR 0.953; 95% CI 0.929–0.976; P < 0.001), the number of of treatment cycles (OR 1.254; 95% CI 1.180–1.333; P < 0.001) are the predictive factors affecting spontaneous abortion. Here, BRD2 is linked to abortion.