MSH2 and cancer: Our Kaplan–Meier analysis also demonstrated that MSH2 variant carriers who also carry the rs2075786 A allele have earlier onset of cancer (Kaplan–Meier analysis log-rank p = 0.0011, Wilcoxon p = 0.0006 and Tarone-Ware p = 0.0007 see Fig. 3), which was not observed for MLH1 and MSH6 variant carriers (log-rank p = 0.3524 and p = 0.3763, respectively).