In conclusion, in type 2 diabetes patients treated with dapagliflozin, an isoenergic protein-enriched diet does not contribute to the change in HbA1c, although it decreases serum insulin and body fat mass, and increases HDL-cholesterol compared with a fat-enriched diet with the same calories and carbohydrate ratio. The gene discussed is INS; the disease is type 2 diabetes mellitus.