INS and type 2 diabetes mellitus: In this study of Japanese type 2 diabetes patients treated with the SGLT2i dapagliflozin, we found that a protein-enriched diet did not contribute to the improvement of HbA1c, although the protein-enriched diet decreased serum insulin and body fat mass, and increased HDL-cholesterol compared with a fat-enriched diet with the same calories and carbohydrate ratio.