Recalling, highly metastatic nature of the HCC, we investigated the link between hyperglycemia and EMT that are critically important in the acquisition of aggressive phenotype, and identified that high glucose treatment: (i) induced ligand independent homodimerization of c-Met (ii) activated Tyr1234/1235 phosphorylation of c-Met and downstream signaling. Here, MET is linked to hepatocellular carcinoma.