SOCS5 and cancer: Although a role for SOCS5 as a promoter of TNBC pathogenesis has not been previously described per se, our results were surprising considering several reports describing SOCS5 as a suppressor of cancer traits in the context of malignancies that included T cell lineage acute lymphoblastic leukemia (T-ALL)34, pancreatic cancer60, hepatocellular carcinoma (HCC)52, or prostate cancer50.