In contrast, a handful of lncRNAs have been shown to induce SOCS5 expression in target cancer cells, and these include HAND2-AS1 in liver cancer54,55, FER1L4 in osteosarcoma56, TUSC7 in endometrial carcinoma57, MEG3 in oral squamous cell carcinoma58, and LINC00668 in glioma59. This evidence concerns the gene MEG3 and cancer.