However, in the individual cancer level, we find that the higher mRNA expression level in glioma (GBMLGG) and lower DNA methylation level in GBMLGG and brain lower-grade glioma (LGG) of STBD1 are significantly associated with a lower survival probability, exhibiting an opposite result against that in the pan-cancer level (Supplementary Data 4, Supplementary Fig. 2). This evidence concerns the gene STBD1 and central nervous system cancer.