For example, an L341V missense mutation found in the LIR motif of sequestosome 1 (SQSTM1/p62), identified in a patient with sporadic amyotrophic lateral sclerosis, disrupts the binding to LC3B and inhibits p62 recruitment into autophagosomes10. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.