MAP1LC3A and cancer: To identify the autophagy pathways perturbed in human cancer, we model a LIRCP-regulating network by integrating protein–protein interactions (PPIs) and transcriptional regulations among the 148 identified LIRCPs, 7 LC3 proteins, and 14 proteins regulated by STBD1 since both mechanisms are important for regulating autophagy32–35 (Fig. 7).