The expression of MIR155HG and LINC00426 was altered in pan-cancer, and the coexpressed genes of MIR155HG and LINC00426 were involved in multiple immune-associated biological processes, including immune cell differentiation and exhausted/activated T-cell genetic programs, indicating that these lncRNAs might assist in the maintenance of the inflamed tumor microenvironment across tumor types, especially MIR155HG, which is an inflamed TME-specific gene in all analyzed tumor types. This evidence concerns the gene MIR155HG and neoplasm.