In contrast, enriched biological processes of inflamed TME-specific mRNA tended to be shared across tumor types, for example, signaling by interleukins (interleukin-4/13/10) and chemokines and PD-1 signaling, suggesting a recruiting and inhibitory tumor microenvironment for such inflamed tumors (Fig. 3b). This evidence concerns the gene PDCD1 and neoplasm.