Behavioral analysis showed that mice injected with IP3R2 shRNAs exhibited deficits in social interaction in the three-chamber test (Fig. 1k, l, Supplementary Fig. 3c), but displayed neither cognitive impairments in the NOR test (Fig. 1m, Supplementary Fig. 9e-g) nor repetitive behaviors in self-grooming assay (Fig. 1n) and marble-burying test (Fig. 1o). Here, ITPR2 is linked to Cognitive impairment.