TLR7 and viral load: An additional advantage of the LPP-mRNA system is their ability to augment TLR7/8 signaling activation in dendritic cells, resulting in secretion of type I interferons.31 Suppression of the interferon response has been shown to be an important mechanism of SARS-CoV-2 in the pathogenesis of the viral disease.32 Thus, the LPP-mRNA vaccine may be especially potent to induce a strong antiviral response.