By comparing the global quantitative proteomics of p300 knockout cells and wild cells, it is found that the protein biomarkers of cancer in 4.5% of the EDRN database are crotonylated, and 32 Kcr proteins are related to cancer genes, accounting for 5.9% of the total genes of COSMIC cancer gene bank, and 6 target proteins of P300 are identified as cancer gene related proteins [61]. The gene discussed is CLEC4F; the disease is cancer.