SQSTM1 and glioblastoma: Peiminine suggest a new strategy for GBM therapy, which induction of autophagic cell death is performed by activating the autophagy-related signaling pathway AMPK-mTOR-ULK and promoting SQSTM1 (P62) [97] as well as inhibiting GMB in vitro and in vivo via arresting the cell cycle and blocking autophagic flux [98].