In particular, NOTCH signaling pathway (BRCA, LUAD, q < 0.05), JAK/STAT signaling pathway (LUAD, COAD, q < 0.05), toll-like receptor signaling (LUAD, COAD, q < 0.05) and apoptosis (LUAD, COAD, q < 0.05) are overrepresented in somatically selected genes in multiple cancer types (q < 0.1). The gene discussed is SOAT1; the disease is cancer.