In studies investigating the physiological processes mediated by netrin-1, functional roles of the molecule have been reported that have involved increased NO synthesis [21], enhanced angiogenesis [22], correction of impaired renal functions due to ischemia [23], protective and anti-inflammatory effects on the vascular endothelium [24], and the maintenance of the integrity of the blood-brain barrier [25]. The gene discussed is NTN1; the disease is ischemia.