The upregulated miRNA signatures are enriched in Prion diseases, Lysine degradation, ECM-receptor interaction, Proteoglycans in cancer, Fatty acid elongation,Pathways in cancer, Cell cycle, FoxO signaling pathway, p53 signaling pathway, TGF-beta signaling pathway, Biosynthesis of unsaturated fatty acids, Viral carcinogenesis, signaling pathways regulating pluripotency of stem cells, Renal cell carcinoma and other biological pathways. This evidence concerns the gene TP53 and cancer.