In sham mice, PerC eCIRP levels were quantified as 29 ± 13 pg/mL, while after sepsis was induced, the levels of PerC eCIRP were significantly increased to 256 ± 53 pg/mL, which was 8.8-fold higher than the sham levels (Fig. 1A). Here, PPARGC1B is linked to Sepsis.