Under sham condition, both WT and CIRP−/− mice had similar contents of Siglec-G+ B-1a cells in the peritoneal cavity, but following induction of sepsis by CLP operation, in WT mice, the decrease in Siglec-G+ B-1a cells in PerC were significantly higher than the CIRP−/− mice PerC B-1a cells. This evidence concerns the gene CIRBP and Sepsis.