In addition, overexpression of Ly6E was shown to inhibit entry of lentiviral pseudotyped virus bearing S from HCoV-OC43, HCoV-229E, HCoV-NL63, MERS-CoV, or SARS-CoV-2 (108, 109) and inhibited infection of their replication-competent viruses (109). Here, LY6E is linked to infection.