In APL, the oncogene promyelocytic leukemia‐retinoic acid receptor alpha genes (PML‐RARA), resulting from reciprocal translocation t(15,17), leads to the compromise of granulocytic differentiation and genetic stability by directly interfering in the transcriptional regulation of RARA and PML, respectively [25]. Here, PML is linked to acute promyelocytic leukemia.