In a supplementary analysis using rs33972313 in the SLC23A1 gene region as instrumental variable, the associations of genetically predicted vitamin C levels with peripheral artery disease (OR, 0.67, 95% CI, 0.46, 1.00; P = 0.048) and other CVDs (data not shown) were consistent with the findings from the analyses based on all instrumental variables. The gene discussed is SLC23A1; the disease is peripheral arterial disease.