Histopathological studies have demonstrated rhabdomyolysis with histologic evidence in patients with COVID-19. Rhabdomyolysis is associated with massive release of myoglobin into systemic circulation, with myoglobinuria, cast formation, and iron deposition in proximal tubular cells causing intratubular obstruction. Direct toxicity on kidney tubular cells causes acute tubular necrosis. This evidence concerns the gene MB and rhabdomyolysis.