Tau‐induced mitochondrial reactive oxygen species (ROS) promote α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR)/N‐methyl‐D‐aspartate receptor (NMDAR)‐mediated Ca2+‐excitotoxicity and neuronal death in 4R tauopathies. This evidence concerns the gene MAPT and tauopathy.