RUNX1 and neoplasm: They are classified as (1) neoplasms with germline predisposition without pre-existing conditions (e.g. CEBPA, DDX41), (2) neoplasms with a history of thrombocytopenia (RUNX1, ANKRD26, ETV6) and (3) neoplasms with other organ dysfunction (e.g. GATA2 or telomere biology disorders).