Significant associations between baseline depression and follow-up:Active CD (P = 0.001, df = 2)Hospitalizations (P = 0.03, df = 2)No significant associations between baseline depression and follow-up:Abdominal surgeries (P = 0.34, df = 2)Anti-TNF prescription (P = 0.15, df = 2). The gene discussed is TNF; the disease is depressive symptom measurement.