Well‐known mutations and syndromes linked to BC and other MPMs include hereditary germline mutations in BRCA1/2 and PTEN (Cowden's syndrome; both breast and thyroid cancer), and TP53 (Li‐Fraumeni syndrome; breast cancer, sarcoma, brain cancer, and leukemia).3, 21, 22. The gene discussed is TP53; the disease is breast cancer.