For example, circ-LRP6 functioned as an oncogenic regulator in esophageal squamous cell carcinoma by targeting the miR-182/Myc signaling [37] and circ-ZNF609 facilitated the development of cervical cancer through the miR-197-3p-mediated E2F6 upregulation [38]. This evidence concerns the gene E2F6 and esophageal squamous cell carcinoma.