Mixture models were also plotted and the results indicated that CDO1, CELF2, ITPRIPL1, KCNH8, RIC3, USP44, ZSCAN1 and ZSCAN23 were hypermethylated and PTK6 and RAB25 were hypomethylated in tumor samples (Fig. 1). This evidence concerns the gene ZSCAN23 and neoplasm.