Mixture models were also plotted and the results indicated that CDO1, CELF2, ITPRIPL1, KCNH8, RIC3, USP44, ZSCAN1 and ZSCAN23 were hypermethylated and PTK6 and RAB25 were hypomethylated in tumor samples (Fig. 1). The gene discussed is USP44; the disease is neoplasm.