Consistently, we also found the protection for tight junctions in mice with endothelial β‐catenin activation in the early stage of ischemic stroke, and BBB protection was not weakened even though antagonistic non‐canonical Wnt signalings were synchronously upregulated, which is the first time to observe the changes of non‐canonical Wnt signalings in the process of BBB protection by manipulating endothelial Wnt/β‐cat signaling. Here, CAT is linked to ischemic stroke.