Since upregulating endothelial Wnt/β‐cat signaling has been considered as a novel therapeutic method for protecting BBB after ischemic stroke, and the antagonisms between canonical and non‐canonical Wnt signalings have been suggested to exist,8, 9 it is necessary to determine the changes of non‐canonical Wnt signalings and their consequences while manipulating endothelial Wnt/β‐cat signaling in the treatment of ischemic stroke. Here, CAT is linked to ischemic stroke.