Guided by structures and multifunctionality, it will be exciting to employ SAXS to learn how to best target conformational transitions with chemical inhibitors that can trap repair intermediates analogously to PARP1 and poly(ADP‐ribose) glycohydrolase (PARG) inhibitors that trap PAR‐complexes to selectively kill cancer cells with low toxicity to normal cells. This evidence concerns the gene PARP1 and cancer.