Therefore, although limited, there is some evidence for alterations to PLA2G6-associated function in idiopathic LBD; however, given that Lewy bodies are an invariant finding in all PLAN cases in the literature, further understanding of how iPLA2 is altered in idiopathic Lewy body disease is a pressing issue. Here, PLA2G6 is linked to neurodegeneration with brain iron accumulation 2A.