It can magnify the severity of toxicity in the case of hypoalbuminemia for highly albumin‐bound substances, since hypoalbuminemia increases the free fraction of the drug in the blood, which increases the risk of toxicity, and can give a clue about the possibility for the ingested substance to undergo dialysis or plasma exchange, where drugs with low protein binding affinity are more likely to be dialyzed, while drugs with high protein binding affinity are more likely to be removed by plasma exchange. The gene discussed is ALB; the disease is Hypoalbuminemia.