TP53 is one of the most commonly deregulated genes in cancers and its pathway is deregulated in up to 85% of gliomas.37 To date, only Zhang et al.17 have assessed radiomic association with TP53 mutation reporting AUC of 0.95 in LGGs through multimodal combination of features from T1, T2, and FLAIR images. The gene discussed is TP53; the disease is central nervous system cancer.