PTEN is a tumor suppressor gene significantly altered in 30%–40% of GBM and strongly associated with poor survival.16 The loss of PTEN function has been mechanistically linked to metastasis and a lack of response to radiotherapy and chemotherapy.2 Only one study to date, Li et al.,16 has assessed radiomic prediction of PTEN status showing excellent AUC of 0.93 by combining texture features from T1 and T2 images. The gene discussed is PTEN; the disease is glioblastoma.