TP53 and cancer: TP53 is one of the most commonly deregulated genes in cancers and its pathway is deregulated in up to 85% of gliomas.37 To date, only Zhang et al.17 have assessed radiomic association with TP53 mutation reporting AUC of 0.95 in LGGs through multimodal combination of features from T1, T2, and FLAIR images.