PSMA2 and acute respiratory distress syndrome: Hyperthermia following administration of dexmedetomidine has been reported (n = 9[203]), although alpha-2 agonists act on the hypothalamic activation threshold (‘set point’), generating mild hypothermia (35–35.5°C).[88,94,204,205] [This report contradicts our clinical experience with alpha-2 agonists in facilitating fever control in the setting of septic shock or ARDS.[90]] Nevertheless, hyperthermia should be borne in mind as a possible adverse drug reaction.