[Alpha-2 agonist administration immediately following endotracheal intubation: In the setting of early severe diffuse ARDS, we do not use midazolam+sufentanil or propofol+remifentanil.[21,89,90] To reduce the duration of mechanical ventilation and intubation,[37,184] we administer an alpha-2 agonist immediately after intubation to achieve an -2 < RASS < 0. Here, PSMA2 is linked to acute respiratory distress syndrome.