Restoration of systemic pressure with vasopressors when diastolic pressure is low.[159] In this respect, alpha-2 agonists lower the dose of vasopressor required in the setting of sepsis[25,160,161] or septic shock,[38, 39, 40] in a dose dependant manner,[162] within ≈ 3 h of administration (Pichot, unpublished data).[38,39]. Here, PSMA2 is linked to Sepsis.