Moreover, circ_0066147 knockdown decreased the levels of proliferation marker PCNA and antiapoptotic protein Bcl-2, while increased proapoptotic proteins Bax and C-caspase3 expression in two PC cell lines (P < 0.0001; Figure 3e), supporting the impact of circ_0066147 knockdown on cell proliferation and apoptosis. The gene discussed is BCL2; the disease is pachyonychia congenita.