In summary, the results indicate that IL-6 induces miR-603 expression, which can subsequently inhibit the expression of FABP1 and increase the expression of CPT1A, PPAR-α, and SREBP1, thus enhances intracellular oxidative stress, thereby promoting the invasion and metastasis of HCC (Figure 6). Here, SREBF1 is linked to hepatocellular carcinoma.