Up-regulated in hypertension: LPS biosynthesis, steroid degradation, ABC transporters, PTS, and bacterial secretion system Down-regulated in hypertension: ubiquinone and other terpenoid-quinone biosynthesis, beta-alanine metabolism, selenocompound metabolism, cyanoamino acid metabolism, d-alanine metabolism, one carbon pool by folate, riboflavin metabolism, and folate biosynthesis. The gene discussed is ABCG2; the disease is hypertensive disorder.