Moreover, it reveals possible underlying mechanisms, with the EGR2 gene required in myelination, extracellular matrix components that mediate blood–brain barrier integrity, DUSP6 and SGK1 that trigger endothelial leukocyte recruitment, and neurotrophins that are essential for neurons—all processes involved in the complex pathophysiology of SVD. This evidence concerns the gene EGR2 and snowflake vitreoretinal degeneration.