Enrichments including GO: 0061448 connective tissue development, GO: 0007584 nutritional response, GO: 0022600 digestive system process, GO: 0045444 adipocyte differentiation, hsa04010 MAPK signal pathway, hsa04657 IL-17 signal pathway, hsa0061 fatty acid biosynthesis, hsa04933 age-old signal pathway in diabetic complications, DOID: 9352 Type 2 diabetes mellitus; DOID: 374 nutritional diseases; DOID: 654 over nutrition; DOID: 9970 obesity have been previously reported to be related to obesity, and thus genes in these clusters were selected for further analysis. The gene discussed is IL17A; the disease is obesity due to melanocortin 4 receptor deficiency.