A study conducted by Barbour et al. (68) showed that “hPGH may lead to insulin resistance by increasing the expression of the p85α monomer, which inhibits p85-p110 heterodimer from binding to insulin receptor substrate-1 (IRS-1) protein” (67) thus preventing further insulin signaling leading to substantially reduced glucose uptake (80, 81). The gene discussed is INS; the disease is Insulin resistance.