SOX4 and pachyonychia congenita: Luciferase reporter assays were performed and the results showed that transfection with miR-1251 mimic significantly decreased the luciferase activity of the WT SOX4 3′-UTR, while the introduction of miR-1251 inhibitor could remarkably increase it, but not that of the MUT SOX4 3′-UTR in PC cells (Figure 7C).