Immunosuppressive genes, such as IL10, IL10RB, LGALS9, and LAG3, were observed to be co-overexpressed with TGFB1 in tumor tissues and predicted poor survival of tumor patients, indicating a potential mechanism by which CCDC137 regulates macrophage polarization, CAFs formation and correlates with several immunosuppressive genes (Kadowaki et al., 2016; Fan et al., 2020; Suzuki et al., 2021; Wang et al., 2021). This evidence concerns the gene TGFB1 and neoplasm.